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Developmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition

Journal of Advanced Research. 2025-04;

Meihui Tao, Li Wang, Chaoyue Chen, Mengfan Tang, Yanping Wang, Jingyue Zhang, Xi Zhao, Qinyu Feng, Junfa Chen, Wei Yan, Rong Lin, Yu Fu

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Mammalian Expression	DEL-1-Fc was expressed and purified by GenScript. Fc protein control was purchased from Sino Biological. BMDMs were subsequently induced with DMEM medium (supplemented with 10 % FBS, 1 % penicillin–streptomycin and 20 ng/ml M?CSF (Genscript)) for 7 days before subsequent experiments.	Get A Quote
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摘要

AAVadeno-associated virusBMDMsbone marrow-derived macrophagesCDcrohn’s diseaseCHXcycloheximideCmpk2cytosine monophosphate kinase 2Cytbcytochrome bDAIdisease activity indexDEGsdifferentially expressed genesDEL-1developmental endothelial locus 1DSSdextran sulfate sodiumdsDNAdouble-stranded DNAIBDinflammatory bowel diseaseLPSlipopolysaccharideNd2NADH: ubiquinone oxidoreductase core subunit 2SPMspecialized pro-resolving mediatorUCulcerative colitis