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Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle.

Diabetologia. 2012;

Habegger K M，Penque B A，Sealls W，Tackett L，Bell L N，Blue E K，Gallagher P J，Sturek M，Alloosh M A，Steinberg H O，Considine R V，Elmendorf

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Catalog Antibody	Phosphorylated-protein kinase B [PKB/Akt2], -Akt substrate of 160 kDa (AS160), -insulin receptor (IR) and - IRS1 proteins were detected with anti-phospho-Akt2 (Ser474) (Genscript, Piscataway, NJ, USA), anti-phospho- Akt substrate (PAS) (Cell Signaling, Danvers, MA, USA), and anti-phosphotyrosine (PY20) (BD Biosciences, Lex- ington, KY, USA), respectively.	Get A Quote

摘要

Diminished cortical filamentous actin (F-actin) has been implicated in skeletal muscle insulin resistance， yet the mechanism(s) is unknown. Here we tested the hypothesis that changes in membrane cholesterol could be a causative factor， as organised F-actin structure emanates from cholesterol-enriched raft microdomains at the plasma membrane.