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9S1R nullomer peptide induces mitochondrial pathology, metabolic suppression, and enhanced immune cell infiltration, in triple-negative breast cancer mouse model

Authors: Nilufar Ali, Cody Wolf, Swarna Kanchan, Shivakumar R Veerabhadraiah, Laura Bond, Matthew W Turner, Cheryl L Jorcyk, Greg Hampikian

Journal: Biomed Pharmacother

PubMed ID: 38118350

Doi: 10.1016/j.biopha.2023.115997.

Products & Services: Peptide Synthesis

Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules

Authors: Christopher M. Hickey, Katherine M. Digianantonio, Kurt Zimmermann? , Alicia Harbin, Connor Quinn, Avani Patel, Peter Gareiss? , Amanda Chapman1 , Bernadette Tiberi1,2, Jennifer Dobrodziej1,3, John Corradi1 , Angela M. Cacace1 , David R. Langley & Miklós Békés

Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY

Doi: 10.1038/s41594-023-01146-w

Products & Services: Peptide Synthesis Gene Synthesis

A lncRNA Dleu2-encoded peptide relieves autoimmunity by facilitating Smad3-mediated Treg induction

Authors: Sibei Tang, Junxun Zhang, Fangzhou Lou, Hong Zhou, Xiaojie Cai, Zhikai Wang, Libo Sun, Yang Sun, Xiangxiao Li, Li Fan, Yan Li, Xinping Jin, Siyu Deng, Qianqian Yin, Jing Bai, Hong Wang, Honglin Wang

Journal: EMBO Rep

PubMed ID: 38291338

Doi: 10.1038/s44319-024-00070-4

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A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease

Authors: Su-Jeong Kim, Brendan Miller, Nicolas G Hartel, Ricardo Ramirez, Regina Gonzalez Braniff, Naphada Leelaprachakul, Amy Huang, Yuzhu Wang, Thalida Em Arpawong, Eileen M Crimmins, Penglong Wang, Xianbang Sun, Chunyu Liu, Daniel Levy, Kelvin Yen, Giselle M Petzinger, Nicholas A Graham, Michael W Jakowec, Pinchas Cohen

Journal: Mol Psychiatry

PubMed ID: 38167865

Doi: 10.1038/s41380-023-02344-0

Products & Services: Peptide Synthesis

Oat Peptides Alleviate Dextran Sulfate Sodium Salt-Induced Colitis by Maintaining the Intestinal Barrier and Modulating the Keap1-Nrf2 Axis

Authors: Zhong-Hao Ji, Wen-Yin Xie , Pei-Sen Zhao , Hong-Yu Wu , Wen-Zhi Ren , Jin-Ping Hu , Wei Gao , Bao Yuan

Journal: Nutrients .

PubMed ID: 38140314

Doi: 10.3390/nu15245055

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Staphylococcus aureus functional amyloids catalyze degradation of β-lactam antibiotics

Authors: Elad Arad , Kasper B Pedersen , Orit Malka, Sisira Mambram Kunnath , Nimrod Golan , Polina Aibinder , Birgit Schi?tt , Hanna Rapaport, Meytal Landau , Raz Jelinek

Journal: Nat Commun .

PubMed ID: 38081813

Doi: s41467-023-43624-1

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Nuclear localization of Argonaute 2 is affected by cell density and may relieve repression by microRNAs

Authors: Krystal C Johnson, Audrius Kilikevicius, Cristina Hofman, Jiaxin Hu, Yang Liu, Selina Aguilar, Jon Graswich, Yi Han, Tao Wang, Jill M Westcott, Rolf A Brekken, Lan Peng, Georgios Karagkounis, David R Corey

Journal: Nucleic Acids Res

PubMed ID: 38109320

Doi: 10.1093/nar/gkad1155

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Electrostatic-Dominated Conformational Fluctuations and Transition States of Phase Separation in Charge-Balanced Protein Polymer

Authors: Sougat Das, Tithi Basu, Saptarshi Majumdar

Journal: ACS Macro Lett

PubMed ID: 38109356

Doi: 10.1021/acsmacrolett.3c00625

Products & Services: Peptide Synthesis

Sensitive Blood-Based Detection of HIV-1 and Mycobacterium tuberculosis Peptides for Disease Diagnosis by Immuno-Affinity Liquid Chromatography-Tandem Mass Spectrometry: A Method Development and Proof-of-Concept Study

Authors: Lin Li, Christopher J Lyon, Sylvia M LaCourse, Wenshu Zheng, Joshua Stern, Jaclyn N Escudero, Wilfred Bundi Murithi, Lilian Njagi, Grace John-Stewart, Thomas R Hawn, Videlis Nduba, Wael Abdelgaliel, Thomas Tombler, David Horne, Li Jiang, Tony Y Hu

Journal: Clin Chem

PubMed ID: 37956323

Doi: 10.1093/clinchem/hvad173

Products & Services: Peptide Synthesis

Synthetic High-Density Lipoprotein-Based Nanomedicine to Silence SOCS1 in Tumor Microenvironment and Trigger Antitumor Immunity against Glioma

Authors: Chunrong Yang , Yujie Li , Yuchen Yang , Qiankun Ni , Zeyu Zhang , Yi Chai , Jinghong Li

Journal: Angew Chem Int Ed Engl .

PubMed ID: 37847126

Doi: 10.1002/anie.202312603

Products & Services: Peptide Synthesis

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