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GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

Authors: Wijnand J C van der Velden, Florent X Smit, Charlotte B Christiansen, Thor C M?ller, Gertrud M Hjort?, Olav Larsen, Sine P Schiellerup, Hans Br?uner-Osborne, Jens J Holst, Bolette Hartmann, Thomas M Frimurer, Mette M Rosenkilde

Journal: ACS Pharmacol Transl Sci

PubMed ID: 33615180

Doi: 10.1021/acsptsci.0c00193

Products & Services: Plasmid DNA Preparation

A novel oral glucagon-like peptide 1 receptor agonist protects against diabetic cardiomyopathy via alleviating cardiac lipotoxicity induced mitochondria dysfunction

Authors: Peng Qian , Hong Tian , Yongkang Wang , Weisheng Lu , Ying Li , Teng Ma, Xiangdong Gao , Wenbing Yao

Journal: Biochem Pharmacol

PubMed ID: 32860826

Doi: https://doi.org/10.1016/j.bcp.2020.114209

Products & Services: Peptide Services

Genetic engineering of novel super long-acting Exendin-4 chimeric protein for effective treatment of metabolic and cognitive complications of obesity

Authors: Jong Youl Lee, Taehoon Park, Eunmi Hong, Reeju Amatya, Kyung-Ah Park, Young-Hoon Park, Kyoung Ah Min, Minki Jin, Sumi Lee, Seungmi Hwang, Gu Seob Roh, Meong Cheol Shin

Journal: Biomaterials

PubMed ID: 32736262

Doi: 10.1016/j.biomaterials.2020.120250

Products & Services: Gene Synthesis

An orally available hypoglycaemic peptide taken up by caveolae transcytosis displays improved hypoglycaemic effects and body weight control in db/db mice

Authors: Weisheng Lu, Hong Tian, Peng Qian, Ying Li, Yongkang Wang, Yang Ge, Wenbo Sai, Xiangdong Gao, Wenbing Yao

Journal: Br J Pharmacol

PubMed ID: 32293707

Doi: 10.1111/bph.15069

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Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis

Authors: Martina?Sundqvist,?André?Holdfeldt,?Shane C.?Wright,?Thor C.?M?ller,?Esther?Siaw,?Karin?Jennbacken,?Henrik?Franzyk,?Michel?Bouvier,?Claes?Dahlgren,?Huamei?Forsman

Journal: biorxiv

Doi: 10.1101/2020.04.30.070011

Products & Services: Plasmid DNA Preparation

Rational development of a high-affinity secretin receptor antagonist

Authors: Maoqing Dong, Kaleeckal G Harikumar, Sweta R Raval, Juliana E Milburn, Carolyn Clark, Rafael Alcala-Torano, Juan C Mobarec, Christopher A Reynolds, Giovanna Ghirlanda, Arthur Christopoulos, Denise Wootten, Patrick M Sexton, Laurence J Miller

Journal: Biochem Pharmacol

PubMed ID: 32217097

Doi: 10.1016/j.bcp.2020.113929

Products & Services: Peptide Synthesis

Degradation of the Incretin Hormone Glucagon-Like Peptide-1 (GLP-1) by Enterococcus faecalis Metalloprotease GelE

Authors: LeValley SL, Tomaro-Duchesneau C, Britton RA

Journal: mSphere

PubMed ID: 32051237

Doi: 10.1128/mSphere.00585-19

Products & Services: Codon Optimization

Dimerization/oligomerization of the extracellular domain of the GLP-1 receptor and the negative cooperativity in its ligand binding revealed by the improved NanoBiT

Authors: Song X, Yu Y, Shen C, Wang Y, Wang N.

Journal: FASEB J

PubMed ID: 31970836

Products & Services: Recombinant Proteins

Long-Lasting Exendin-4 Fusion Protein Improves Memory Deficits in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

Authors: Park KA, Jin Z, Lee JY, An HS, Choi EB, Kim KE, Shin HJ, Jeong EA, Min KA, Shin MC, Roh GS.

Journal: Pharmaceutics

PubMed ID: 32079069

Products & Services: Gene Synthesis

Glucagon-like peptide-1 cleavage product GLP-1(9-36) reduces neuroinflammation from stroke via the activation of insulin-like growth factor 1 receptor in astrocytes

Authors: Jing Huang, Yunhan Liu, Liusiyuan Cheng, Jihong Li, Tangrui Zhang, Gang Zhao, Huinan Zhang

Journal: Eur J Pharmacol

PubMed ID: 32949596

Doi: 10.1016/j.ejphar.2020.173581

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