国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務及產品已被Cell, Nature, Science, PNAS等1300多家生物醫藥類雜志引用近萬次,處于行業領先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學等約400家全球著名機構使用GenScript的基因合成、多肽服務、抗體服務和蛋白服務等成功地發表科研成果,再次證明GenScript 有能力幫助業內科學家Make research easy.

The intrinsic substrate specificity of the human tyrosine kinome

Nature. 2024-05; 
Tomer M. Yaron-Barir, Brian A. Joughin, Emily M. Huntsman, Alexander Kerelsky, Daniel M. Cizin, Benjamin M. Cohen, Amit Regev, Junho Song, Neil Vasan, Ting-Yu Lin, Jose M. Orozco, Christina Schoenherr, Cari Sagum, Mark T. Bedford, R. Max Wynn, Shih-Chia Tso, David T. Chuang, Lei Li, Shawn S.-C. Li, Pau Creixell, Konstantin Krismer, Mina Takegami, Harin Lee, Bin Zhang, Jingyi Lu, Ian Cossentino, Sean D. Landry, Mohamed Uduman, John Blenis, Olivier Elemento, Margaret C. Frame, Peter V. Hornbeck, Lewis C. Cantley, Benjamin E. Turk, Michael B. Yaffe & Jared L. Johnson
Products/Services Used Details Operation
Codon Optimization For expression and purification from bacteria, DNA sequences for the human Tyr kinases His6–PKMYT1 (full length), BMPR2–His6 (amino acids 172–504)20, His6-TESK1 (amino acids 1–345) and the C. elegans Tyr kinase His6–ABL1 (amino acids 297–584) were codon-optimized for Escherichia coli expression using the GeneSmart prediction software (Genscript). Get A Quote

摘要

Phosphorylation of proteins on tyrosine (Tyr) residues evolved in metazoan organisms as a mechanism of coordinating tissue growth1. Multicellular eukaryotes typically have more than 50 distinct protein Tyr kinases that catalyse the phosphorylation of thousands of Tyr residues throughout the proteome1-3. How a given Tyr kinase can phosphorylate a specific subset of proteins at unique Tyr sites is only partially understood4-7. Here we used combinatorial peptide arrays to profile the substrate sequence specificity of all human Tyr kinases. Globally, the Tyr kinases demonstrate considerable diversity in optimal patterns of residues surrounding the site of phosphorylation, revealing the functional organization of th... More

關鍵詞

              主站蜘蛛池模板: 蛟河市| 乐亭县| 闽清县| 白河县| 徐水县| 陇川县| SHOW| 济源市| 徐州市| 启东市| 卓尼县| 大田县| 资源县| 张北县| 平度市| 锡林郭勒盟| 南澳县| 庆安县| 牡丹江市| 淮安市| 济南市| 兰考县| 梁山县| 合阳县| 江都市| 太湖县| 五原县| 金川县| 龙游县| 永川市| 东兴市| 西昌市| 西城区| 乃东县| 贺兰县| 永泰县| 土默特左旗| 长岭县| 灌阳县| 龙山县| 定西市|