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Anticancer Effects of the Trivalent Organoarsenical 2-Amino-4-(dihydroxyarsinoyl) Butanoate

Organometallics. 2024-05; 
Venkadesh Sarkarai Nadar, Kunie Yoshinaga-Sakurai, Barry P Rosen
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Codon Optimization … The gene for KGA without the mitochondrial localization sequence (residues 72–598) was chemically synthesized by GenScript USA Inc. (New Jersey) with codon optimization for … Get A Quote

摘要

According to the National Cancer Institute, breast cancer is a leading cause of death in women. The lack of progesterone and estrogen receptors in triple-negative breast cancer (TNBC) cells results in a lack of response to hormonal, monoclonal, or tyrosine kinase inhibitor therapies. Despite intensive drug discovery, there is still no approved targeted treatment for TNBC. The metalloid arsenic has been used in herbal medicines, antibiotics, and chemotherapeutic drugs for centuries. This paper demonstrates that a trivalent arsenic-containing, nonproteogenic amino acid, R-AST-OH (2-amino-4-(dihydroxyarsinoyl) butanoate), inhibits kidney-type glutaminase (KGA), the enzyme that controls glutamine metabolism and is ... More

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