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The Humanization and Maturation of an Anti-PrPc Antibody

Bioengineering (Basel). 2024-02; 
Cheng Zhang, Fanlei Ran, Lei Du, Xiaohui Wang, Lei Liu, Jinming Liu, Quan Chen, Yang Cao, Lijun Bi, Haiying Hang
Products/Services Used Details Operation
Codon Optimization … Antibody genes were codon optimized and synthesized by GenScript Biotech Corporation (… at its N-terminus) were synthesized by GenScript Biotech Corporation. The sequence of PrPc-… Get A Quote

摘要

The cellular prion protein (PrPc) is a cell surface glycoprotein that is highly expressed in a variety of cancer tissues in addition to the nervous system, and its elevated expression is correlated to poor prognosis in many cancer patients. Our team previously found that patients with colorectal cancer (CRC) with high-level PrPc expression had significantly poorer survival than those with no or low-level PrPc expression. Mouse antibodies for PrPc inhibited tumor initiation and liver metastasis of PrPc-positive human CRC cells in mouse model experiments. PrPc is a candidate target for CRC therapy. In this study, we newly cloned a mouse anti-PrPc antibody (Clone 6) and humanized it, then affinity-matured this ant... More

關鍵詞

affinity maturation, anti-PrPc antibody, colorectal cancer, humanization, mammalian cell display
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