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Secretory carrier-associated membrane protein 5 regulates cell-surface targeting of T-type calcium channels

Channels (Austin). 2023-12; 
Emilio R Mustafá, Konstantin Wei?, Norbert Weiss
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Gene Synthesis … Here, we show that similar to SCAMP2, the co-expression of SCAMP5 in tsA-201 cells … mutants by site-directed mutagenesis (performed by GenScript). The fidelity of all constructs was … Get A Quote

摘要

Missense mutations in the human secretary carrier-associated membrane protein 5 (SCAMP5) cause a variety of neurological disorders including neurodevelopmental delay, epilepsy, and Parkinson's disease. We recently documented the importance of SCAMP2 in the regulation of T-type calcium channel expression in the plasma membrane. Here, we show that similar to SCAMP2, the co-expression of SCAMP5 in tsA-201 cells expressing recombinant Ca3.1, Ca3.2, and Ca3.3 channels nearly abolished whole-cell T-type currents. Recording of intramembrane charge movements revealed that SCAMP5-induced inhibition of T-type currents is primarily caused by the reduced expression of functional channels in the plasma membrane. Moreover, w... More

關鍵詞

Calcium channels, Channelopathy, Ion channels, SCAMP5, Secretory carrier-associated membrane protein 5, T-type channels
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