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Eliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment

Mol Ther Oncolytics. 2021-01; 
Zhiwu Tan, Mei Sum Chiu, Chi Wing Yan, Kwan Man, Zhiwei Chen
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Proteins, Expression, Isolation and Analysis Soluble proteins in the supernatant were also detected after immunoprecipitation with anti-DYKDDDDK G1 affinity resin (GenScript) Get A Quote

摘要

The potency of cancer vaccines is often compromised by a variety of immunoinhibitory mechanisms, including stimulation of the programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1) immune checkpoint pathway. Here, to overcome inhibition, we determined the potential of recombinant adeno-associated virus (rAAV)-vectored, PD1-based vaccination in the tumor microenvironment (TME) to activate antigen-specific T?cell responses in the immune-competent murine mesothelioma model. We found that our rAAV-soluble PD1 (sPD1)-TWIST1 vaccine elicited and maintained TWIST1-specific cytotoxic T lymphocyte (CTL) responses and the PD-1 blocker systemically against lethal mesothelioma challenge after intramuscul... More

關鍵詞

PD-1, PD1-based vaccination, T cell immunity, TWIST1 antigen, adeno-associated virus, immune checkpoint blockade, immunotherapy, mesothelioma
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