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Characterization and functional analysis of the proteins Prohibitin 1 and 2 in Trypanosoma cruzi

PLoS Negl Trop Dis. 2021-04; 
Ana K Ibarrola-Vannucci, Luis M De Pablos, Lissette Retana-Moreira, Alberto Cornet-Gomez, Teresa Cruz-Bustos, Alejandro G Schijman, José L Ramírez, Susana Vílchez, Antonio Osuna
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Catalog Antibody the TAPtag was identified using the CBP Tag mAb mouse antibody (GenScript, Piscataway, NJ, USA) Get A Quote

摘要

background: Chagas disease is the third most important neglected tropical disease. There is no vaccine available, and only two drugs are generally prescribed for the treatment, both of which with a wide range of side effects. Our study of T. cruzi PHBs revealed a pleiotropic function in different stages of the parasite, participating actively in the transformation of the non-infective replicative epimastigote form into metacyclic trypomastigotes and also in the multiplication of intracellular amastigotes. methodology/principal findings: To obtain and confirm our results, we applied several tools and techniques such as electron microscopy, immuno-electron microscopy, bioinformatics analysis and molecular biology... More

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