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Editing flagellin derivatives for exploration of potent radioprotective agents

Eur J Pharmacol. 2021-06; 
Tong Shi, Jun Jiang, Meng Gao, Ronglin Ma, Xuejun Chen, Ruihua Zhang, Jianfu Xu, Weili Wang, Shujuan Xu, Xi Liu, Huizhen Zheng, Chen Wang, Liqin Li, Ruibin Li
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Gene Synthesis … The Fd genes were synthesized by Genscript (Piscataway, USA), amplified by Polymerase Chain Reaction (PCR), and ligated into a modified pCold-sumo vector, which contains an N-terminal His6 tag, Smt3 Fusion Protein and SUMO Protease 1 cleavage site via seamless?… Get A Quote

摘要

Exploration of medical radiation countermeasures (MRCs) has great implications in protection of mammals from radiation damages. While flagellin has been recently reported to show radioprotective effects, the relationships between flagellin structure and radioprotective activity are rarely explored. Herein, we deliberately edited the amino acid sequence of flagellin in its binding domain with toll-like receptor 5 (TLR5) for exploration of potent flagellin derivatives (Fds). An in vitro screening paradigm was developed to examine the radioprotective effects of six engineered Fds. Notably, mutation of 103 threonine on flagellin into asparagine resulted in a potent MRC candidate (Fd-T103N) displaying 1.28-fold incr... More

關鍵詞

Flagellin derivatives, High throughput, Immune activation, Radiation, Toxicology
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