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Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression

Int Immunopharmacol. 2020-11; 
Chang Chen, Jingya Gu, Jue Wang, Yu Wu, Aihua Yang, Tingting Chen, Tingting Zhou, Zhaoguo Liu
Products/Services Used Details Operation
Gene Synthesis … China). The primers used in real-time PCR were from GenScript Co. Ltd. (Nanjing, China). 3-TYP (120241-79-4) was purchased from Selleck. MegaTran 1.0 transfection reagent was from OriGene (Rockville, MD, USA). SIRT3?… Get A Quote

摘要

Physcion 8-O-β-glucopyranoside (PSG), an anthraquinone extracted from Rumex japonicus Houtt, has various pharmacological effects, however, the effect of PSG on liver fibrosis and its related mechanism remain to be determined. We here showed that PSG ameliorated liver injury and liver fibrosis, decreased collagen deposition and inhibited inflammation in carbon tetrachloride (CCl)-induced rats. Consistent with the in vivo results, PSG suppressed the transforming growth factor-β1 (TGF-β1)-induced cell viability, liver fibrosis and secretion of inflammatory factors in hepatic stellate cells (HSCs). Interestingly, PSG increased the enzyme activity and promoter activity of sirtuin 3 (SIRT3) in fibrotic liver and a... More

關鍵詞

Inflammation, Liver fibrosis, NF-κB P65, Physcion 8-O-β-glucopyranoside, SIRT3
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