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Organoarsenicals inhibit bacterial peptidoglycan biosynthesis by targeting the essential enzyme MurA

Chemosphere. 2020-09; 
Luis D.Garbinski,Barry P.Rosen,Masafumi Yoshinaga
Products/Services Used Details Operation
Gene Synthesis Codon-optimized S. putrefaciens 200 wild-type murA was commercially synthesized and cloned into expression vector pET28a (GenScript, Piscataway, NJ). Get A Quote

摘要

Trivalent organoarsenicals such as methylarsenite (MAs(III)) are considerably more toxic than inorganic arsenate (As(V)) or arsenite (As(III)). In microbial communities MAs(III) exhibits significant antimicrobial activity. Although MAs(III) and other organoarsenicals contribute to the global arsenic biogeocycle, how they exert antibiotic-like properties is largely unknown. To identify possible targets of MAs(III), a genomic library of the gram-negative bacterium, Shewanella putrefaciens 200, was expressed in Escherichia coli with selection for MAs(III) resistance. One clone contained the S. putrefaciens murA gene (SpmurA), which catalyzes the first committed step in peptidoglycan biosynthesis. Overexpression of... More

關(guān)鍵詞

Organoarsenicals;Peptidoglycan;Methylarsenite;Fosfomycin;Bacterial resistance
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