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Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells

J Lipid Res. 2020; 
Lupien LE,, Bloch K, Dehairs J, Traphagen NA, Feng WW,, Davis WL, Dennis T,,, Swinnen JV, Wells WA,, Smits NC,, Kuemmerle NB,, Miller TW, Kinlaw WB,.
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Catalog Antibody … Lysates were sonicated for 15 s and centrifuged at 17,000 g for 10 min at 4°C, and protein was quantified by BCA assay (Pierce) Protein was denatured in LDS sample buffer (GenScript) with 125% β-mercaptoethanol and heated to 95°C for 1 min … Get A Quote

摘要

We previously described the expression of CD36 and LPL by breast cancer (BC) cells and tissues and the growth-promoting effect of VLDL observed only in the presence of LPL. We now report a model in which LPL is bound to a heparan sulfate proteoglycan motif on the BC cell surface and acts in concert with the VLDL receptor to internalize VLDLs via receptor-mediated endocytosis. We also demonstrate that gene-expression programs for lipid synthesis versus uptake respond robustly to triglyceride-rich lipoprotein availability. The literature emphasizes de novo FA synthesis and exogenous free FA uptake using CD36 as paramount mechanisms for lipid acquisition by cancer cells. We find that the uptake of intact lipoprote... More

關(guān)鍵詞

fatty acids; lipase; metabolism; synthesis
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