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Improving acetyl-CoA biosynthesis in via the overexpression of pantothenate kinase and PDH bypass

Biotechnol Biofuels. 2017-01; 
LiuWenshan, ZhangBo, JiangRong
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Codon Optimization … TDH3p-SeAcs L641P -PGIt expression cassette, with TDH3p promoter and PGIt terminator from S. cerevisiae and SeAcs L641P from Salmonella enteric, was codon optimized and synthesized by GenScript (Piscataway, New Jersey, USA), which was digested by NheI and XhoI … Get A Quote

摘要

Acetyl-CoA is an important precursor in . Various approaches have been adopted to improve its cytosolic level previously with the emphasis on engineering the "acetyl-" part of acetyl-CoA. To the best of our knowledge, there have been no reports on engineering the "-CoA" part so far.

關(guān)鍵詞

Acetyl-CoA,Naringenin production,Pantothenate,Pantothenate kinase,Pyruvate dehydrogenase bypass,Saccharomyces cerevi
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