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Chronic exposure to parabens promotes non-alcoholic fatty liver disease in association with the changes of the gut microbiota and lipid metabolism

Food Funct. 2024-02; 
Yilin Ren, Xinyi Shi, Jing Mu, Shenyin Liu, Xin Qian, Wenlong Pei, Shanhong Ni, Zhengduo Zhang, Lei Li, Zhan Zhang
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Gene Synthesis … Biotech, Nanjing, China). The primers, listed in ESI Table 2,? were synthesized by GenScript (Nanjing, China). GAPDH was used as the internal reference gene to calculate the results. … Get A Quote

摘要

Non-alcoholic fatty liver disease (NAFLD) has become a serious public health issue due to changing dietary patterns and composition. However, the relationship between NAFLD occurrence and food additives, such as preservatives, remains unknown. This study aimed to evaluate the toxicity of parabens, namely methylparaben (MeP) and ethylparaben (EtP), in relation to NAFLD occurrence in mice under different dietary conditions. Exposure to MeP and EtP exacerbated high-fat diet (HFD)-induced obesity, glucose intolerance, higher serum lipid concentrations, and fat accumulation by upregulating genes involved in lipid metabolism. Untargeted metabolomics revealed that arachidonic acid (AA) metabolism was the top enriched ... More

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