国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務及產品已被Cell, Nature, Science, PNAS等1300多家生物醫藥類雜志引用近萬次,處于行業領先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學等約400家全球著名機構使用GenScript的基因合成、多肽服務、抗體服務和蛋白服務等成功地發表科研成果,再次證明GenScript 有能力幫助業內科學家Make research easy.

Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2

Cell Rep. 2023-11; 
Shengnan Zhu, Qingning Yuan, Xinzhu Li, Xinheng He, Shiyi Shen, Dongxue Wang, Junrui Li, Xi Cheng, Xiaoqun Duan, H Eric Xu, Jia Duan
Products/Services Used Details Operation
Catalog Antibody … complex are evolutionally conserved across yeast, mammals, and plants. In Arabidopsis … by immunoblotting using an anti-GST antibody (GenScript, Nanjing, China; A00866-100, lot: … Get A Quote

摘要

Niacin, an age-old lipid-lowering drug, acts through the hydroxycarboxylic acid receptor 2 (HCAR2), a G-protein-coupled receptor (GPCR). Yet, its use is hindered by side effects like skin flushing. To address this, specific HCAR2 agonists, like MK-6892 and GSK256073, with fewer adverse effects have been created. However, the activation mechanism of HCAR2 by niacin and these new agonists is not well understood. Here, we present three cryoelectron microscopy structures of Gi-coupled HCAR2 bound to niacin, MK-6892, and GSK256073. Our findings show that different ligands induce varying binding pockets in HCAR2, influenced by aromatic amino acid clusters (W91, H161, W188, H189, and F193) from receptors ECL1, TM4, an... More

關鍵詞

CP: Metabolism, CP: Molecular biology, GPCR, GSK256073, HCA receptor activation, HCAR2, MK-6892, antilipolysis, cryo-EM, diverse ligand-binding pockets, ligand selectivity, niacin
              主站蜘蛛池模板: 镇坪县| 察哈| 富锦市| 徐州市| 怀化市| 常州市| 西畴县| 安泽县| 津南区| 原平市| 大邑县| 乌苏市| 荆门市| 渝中区| 富裕县| 洱源县| 大同市| 喀喇| 丹寨县| 阳泉市| 自贡市| 吕梁市| 三门峡市| 双江| 鹤壁市| 临沭县| 原平市| 张家口市| 如皋市| 余干县| 利辛县| 宁海县| 沙田区| 龙川县| 高清| 伊宁县| 蕲春县| 龙州县| 伊金霍洛旗| 天津市| 阿尔山市|