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Specifically targeting antimicrobial peptides for inhibition of Candidatus Liberibacter asiaticus

J Appl Microbiol. 2024-04; 
Samavath Mallawarachchi, Haoqi Wang, Nirmitee Mulgaonkar, Sonia Irigoyen, Carmen Padilla, Kranthi Mandadi, James Borneman, Sandun Fernando
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Proteins, Expression, Isolation and Analysis … protein of CLas is selected as the main target protein for in silico drug screening. β-barrel outer membrane proteins (OMPs) are a type of protein … -synthesized by GenScript based on … Get A Quote

摘要

objective: Huanglongbing (citrus greening) is a plant disease putatively caused by the unculturable Gram-negative bacterium Candidatus Liberibacter asiaticus (CLas), and it has caused severe damage to citrus plantations worldwide. There are no definitive treatments for this disease, and conventional disease control techniques have shown limited efficacy. This work presents an in silico evaluation of using specifically targeting anti-microbial peptides (STAMPs) consisting of a targeting segment and an antimicrobial segment to inhibit citrus greening by inhibiting the BamA protein of CLas, which is an outer membrane protein crucial for bacterial viability. results: Initially, a set of peptides with a high affinit... More

關鍵詞

BamA, CLas, Huanglongbing, antimicrobial peptides, citrus greening, targeting
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