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Exploring solute binding proteins in Pseudomonas aeruginosa that bind to γ-aminobutyrate and 5-aminovalerate and their role in activating sensor kinases

Microbiologyopen. 2024-06; 
Jean Paul Cerna-Vargas, Tino Krell
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Gene Synthesis … of SBPs PA0602, AgtB, and PA4985, as well as the LBDs of the SHKs AgtS (PA0600, amino acids 22–274) and AruS (PA4982, amino acids 31–141) were synthesized by GenScript. … Get A Quote

摘要

The standard method of receptor activation involves the binding of signals or signal-loaded solute binding proteins (SBPs) to sensor domains. Many sensor histidine kinases (SHKs), which are activated by SBP binding, are encoded adjacent to their corresponding sbp gene. We examined three SBPs of Pseudomonas aeruginosa PAO1, encoded near the genes for the AgtS (PA0600) and AruS (PA4982) SHKs, to determine how common this arrangement is. Ligand screening and microcalorimetric studies revealed that the SBPs PA0602 and PA4985 preferentially bind to GABA (KD?=?2.3 and 0.58?μM, respectively), followed by 5-aminovalerate (KD?=?30 and 1.6?μM, respectively) and ethanoldiamine (KD?=?2.3 and 0.58?μM, r... More

關(guān)鍵詞

Pseudomonas aeruginosa, molecular recognition, sensor histidine kinase, signal transduction, solute binding proteins
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