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PARP1 interacts with WDR5 to enhance target gene recognition and facilitate tumorigenesis

Cancer Lett. 2024-05; 
Yali Qin, Xiaochuan Dong, Manman Lu, Lingyun Jing, Qingchuan Chen, Fei Guan, Zhengkai Xiang, Jiaojuan Huang, Chengxuan Yang, Ximiao He, Jing Qu, Zhenhua Yang
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Proteins, Expression, Isolation and Analysis … Then, the anti-GST magnetic beads (GenScript) were added and further incubated for 2 h at 4 C. The mixture was extensively washed by wash buffer and was checked for bound … Get A Quote

摘要

Poly (ADP-ribose) polymerase-1 (PARP1) is a nuclear protein that attaches negatively charged poly (ADP-ribose) (PAR) to itself and other target proteins. While its function in DNA damage repair is well established, its role in target chromatin recognition and regulation of gene expression remains to be better understood. This study showed that PARP1 interacts with SET1/MLL complexes by binding directly to WDR5. Notably, although PARP1 does not modulate WDR5 PARylation or the global level of H3K4 methylation, it exerts locus-specific effects on WDR5 binding and H3K4 methylation. Interestingly, PARP1 and WDR5 show extensive co-localization on chromatin, with WDR5 facilitating the recognition and expression of tar... More

關鍵詞

Chromatin binding, MLL complexes, PARP1, Transcription, WDR5
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