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Omicron variant neutralizing antibodies following BNT162b2 BA4/5 versus mRNA-1273 BA1 bivalent vaccination in patients with end-stage kidney disease

Nat Commun. 2023-09; 
Kevin Yau, Alexandra Kurtesi, Freda Qi, Melanie Delgado-Brand, Tulunay R Tursun, Queenie Hu, Miten Dhruve, Christopher Kandel, Omosomi Enilama, Adeera Levin, Yidi Jiang, W Rod Hardy, Darren A Yuen, Jeffrey Perl, Christopher T Chan, Jerome A Leis, Matthew J Oliver, Karen Colwill, Anne-Claude Gingras, Michelle A Hladunewich
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摘要

Neutralization of Omicron subvariants by different bivalent vaccines has not been well evaluated. This study characterizes neutralization against Omicron subvariants in 98 individuals on dialysis or with a kidney transplant receiving the BNT162b2 (BA.4/BA.5) or mRNA-1273 (BA.1) bivalent COVID-19 vaccine. Neutralization against Omicron BA.1, BA.5, BQ.1.1, and XBB.1.5 increased by 8-fold one month following bivalent vaccination. In comparison to wild-type (D614G), neutralizing antibodies against Omicron-specific variants were 7.3-fold lower against BA.1, 8.3-fold lower against BA.5, 45.8-fold lower against BQ.1.1, and 48.2-fold lower against XBB.1.5. Viral neutralization was not significantly different by bivalen... More

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