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Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

Cell Rep. 2021-01; 
Anthony T Tan, Martin Linster, Chee Wah Tan, Nina Le Bert, Wan Ni Chia, Kamini Kunasegaran, Yan Zhuang, Christine Y L Tham, Adeline Chia, Gavin J D Smith, Barnaby Young, Shirin Kalimuddin, Jenny G H Low, David Lye, Lin-Fa Wang, Antonio Bertoletti
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Catalog Antibody HRP-conjugated RBD (Genscript) were pre-incubated with 1:20 diluted serum at 37°C for 1h Get A Quote

摘要

Virus-specific humoral and cellular immunity act synergistically to protect the host from viral infection. We interrogate the dynamic changes of virological and immunological parameters in 12 patients with symptomatic acute SARS-CoV-2 infection from disease onset to convalescence or death. We quantify SARS-CoV-2 viral RNA in the respiratory tract in parallel with antibodies and circulating T?cells specific for various structural (nucleoprotein [NP], membrane [M], ORF3a, and spike) and non-structural (ORF7/8, NSP7, and NSP13) proteins. Although rapid induction and quantity of humoral responses associate with an increase in disease severity, early induction of interferon (IFN)-γ-secreting SARS-CoV-2-specific T?... More

關鍵詞

Acute phase4, Antibodies, Convalescence, Humoral response, Longitudinal, T cell response
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