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Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity

EMBO Rep. 2021-06; 
Lise Chauveau, Anne Bridgeman, Tiong K Tan, Ryan Beveridge, Joe N Frost, Pramila Rijal, Isabela Pedroza-Pacheco, Thomas Partridge, Javier Gilbert-Jaramillo, Michael L Knight, Xu Liu, Rebecca A Russell, Persephone Borrow, Hal Drakesmith, Alain R Townsend, Jan Rehwinkel
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摘要

Cyclic GMP-AMP (cGAMP) is an immunostimulatory molecule produced by cGAS that activates STING. cGAMP is an adjuvant when administered alongside antigens. cGAMP is also incorporated into enveloped virus particles during budding. Here, we investigate whether inclusion of cGAMP within viral vaccine vectors enhances their immunogenicity. We immunise mice with virus-like particles (VLPs) containing HIV-1 Gag and the vesicular stomatitis virus envelope glycoprotein G (VSV-G). cGAMP loading of VLPs augments CD4 and CD8 T-cell responses. It also increases VLP- and VSV-G-specific antibody titres in a STING-dependent manner and enhances virus neutralisation, accompanied by increased numbers of T follicular helper cells. ... More

關(guān)鍵詞

SARS-CoV-2, cGAMP, influenza A virus, type I interferon, viral vaccine vector
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