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FAD-Deficient P187S mutation of NAD(P)H:quinone oxidoreductase 1 (NQO1*2) binds and accelerates β-amyloid aggregation

Biosci Rep. 2022-10; 
Sudipta Panja, David Siegel, Simonetta Camandola, Rafael de Cabo, David Ross, Krishna Mallela
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Click Peptide Services … Human Aβ1-42 as a click peptide was purchased from GenScript (Catalog# RP10017) and … AnaSpec (Catalog# AS-64161). Ultrapure Milli Q water was used throughout the study. … Get A Quote

摘要

Alzheimer's disease is one of the most prominent neurodegenerative diseases. Results from animal and cellular models suggest that FAD-deficient forms of NQO1 may accelerate the aggregation of Alzheimer's amyloid beta peptide Ab1-42. Here we examined in-vitro whether NQO1 and its FAD-deficient P187S mutation (NQO1*2) directly interact with Ab1-42 and modify its rate of aggregation. When monitored using the fluorescence of either non-covalent thioflavin T or HiLyte Fluor 647 dye covalently attached to the Ab1-42 peptide, the aggregation kinetics of Ab1-42 were markedly more rapid in the presence of NQO1*2 than the wild-type NQO1. Experiments using apo-NQO1 indicate that this increase is linked to the inability of... More

關(guān)鍵詞

Alzheimers disease, Biophysics, NQO1, binding, fluorescence, kinetics
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