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Roles of individual human Dishevelled paralogs in the Wnt signalling pathways

Cell Signal. 2021-05; 
Petra Paclíková, Tomasz Witold Radaszkiewicz, David Potě?il, Jakub Harno?, Zbyněk Zdráhal, Vítězslav Bryja
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Catalog Antibody … All rights reserved. as substrate. The AMPKγ3 (#YZ6229) and α2 (#YZ7205) antibodies used for IP were custom-made by Yenzyn (San Francisco, CA, USA) and the AMPKα1 (#2015) antibody was custom-made by Genscript (Piscataway, NJ, USA). 2.14. Muscle nucleotides?… Get A Quote

摘要

Dishevelled (DVL) proteins are key mediators of most Wnt pathways. In all vertebrates, three DVL paralogs are present (DVL1, DVL2 and DVL3) but it is poorly defined to what extent they are functionally redundant. Here, we generated T-REx HEK 293 cells with only one DVL paralog (i.e., DVL1-only, DVL2-only, and DVL3-only) and compared their response to Wnt-3a and Wnt-5a ligands with wild type and DVL triple knockout cells. We show that DVL is essential, in addition to the previously shown Wnt-3a-induced phosphorylation of LRP6 and transcriptional activation of TCF/LEF-dependent reporter, also for Wnt-3a-induced degradation of AXIN1 and Wnt-5a-induced phosphorylation of ROR1. We have quantified the molar ratios of... More

關(guān)鍵詞

Axin1, CRISPR/Cas9, Dishevelled 1/2/3, ROR1, Wnt signalling
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