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Development of in situ gel containing asiaticoside/cyclodextrin complexes Evaluation in culture human periodontal ligament cells (HPLDCs)

Int J Pharm. 2020-07-01; 
Hay Man Saung Hnin Soe, Jittima Amie Luckanagul, Prasit Pavasant, Phatsawee Jansook
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Catalog Antibody … The primers ManTF: CCT CGC CAT ATG GGG GAG TTG C and ManR: TAC CGC GGA TCC TCA TTC AAC GAT T were used for PCR amplification of tbman. The primers were designed by the Primer 5.0 and synthesized by Genscript (Nanjing, China) … Get A Quote

摘要

Asiaticoside (AS), an active herbal compound isolated from Centella asiatica, has the potential benefit in promoting type I collagen (COL I) synthesis and osteogenic differentiation in human periodontal ligament cells (HPDLCs). However, it has low aqueous solubility which may hamper the bioavailability. Thus, the aim of this study was to develop thermoresponsive in situ gel containing AS/cyclodextrin (CD) complexes. The non-encapsulated formulations consisted of AS/hydroxypropyl β-CD (HPβCD) complexes and encapsulated formulations containing AS loaded sulfobutylether β-CD/chitosan nanoparticles (SBEβCD/CS NPs) were prepared. The appearance, pH and viscosity of all formulations were within the acceptable ran... More

關(guān)鍵詞

Asiaticoside, Collagen type I, Cyclodextrin, Encapsulation, In situ gel, Periodontitis
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