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Anticancer Effects of ACT001 via NF-κB Suppression in Murine Triple-Negative Breast Cancer Cell Line 4T1

Cancer Manag Res. 2020-06-01; 
Yanyang Liu, Li Wang, Jiewei Liu, Xiaoxiao Xie, Haoyue Hu, Feng Luo
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Recombinant Proteins … MDSCs were cultured in DMEM complete medium with or without the addition of 100 ng/mL mouse granulocyte-macrophage colony stimulating factor (GM-CSF) (GenScript, Nanjing, Jiangsu, China) for 4 d. Cells were then stained with CD11b-PE-CY7 (eBioscience) and Gr-1 … Get A Quote

摘要

unassigned: ACT001 is a novel sesquiterpene lactone derivative with anticancer effects, including the reversal of tamoxifen resistance in estrogen receptor-positive breast cancer cells. However, few studies have investigated the anticancer effects of ACT001 in triple-negative breast cancer (TNBC), a highly aggressive cancer with a poor prognosis. This study aimed to investigate the effects of ACT001 on TNBC and the potential mechanism underlying these effects. unassigned: The anticancer effects of ACT001 on the murine TNBC cell line 4T1 were evaluated by Cell Counting Kit-8 assay, animal experiments, TUNEL staining, flow cytometry, immunofluorescence, enzyme-linked immunosorbent assay, and Western blotting anal... More

關鍵詞

ACT001, NF-κB, angiogenesis, myeloid-derived suppressor cells, triple-negative breast cancer
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