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Flavonoid‐Derived Human Phenyl‐γ‐Valerolactone Metabolites Selectively Detoxify Amyloid‐β Oligomers and Prevent Memory Impairment in a Mouse Model of …

Molecular Nutrition & Food Research. 2020-01;

Roberta Ruotolo Ilaria Minato Pietro La Vitola Luisa Artioli Claudio Curti Valentina Franceschi Nicoletta Brindani Davide Amidani Laura Colombo Mario Salmona Gianluigi Forloni Gaetano Donofrio Claudia Balducci Daniele Del Rio Simone Ottonello

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Gene Synthesis	… All rights reserved. 8 2.5 In vitro Aβ42 oligomer and fibril formation A depsipeptide derivative of the human Aβ42 peptide (#RP10017 from GenScript; or in-house synthesized[30]) was used to prepare seed-free solutions of monomeric Aβ42 as described …	Get A Quote

摘要

Amyloid‐β oligomers (AβO) are causally related to Alzheimer's disease (AD). Dietary natural compounds, especially flavonoids and flavan‐3‐ols, hold great promise as potential AD‐preventive agents but their host and gut microbiota metabolism complicates identification of the most relevant bioactive species. This study aims to investigate the ability of a comprehensive set of phenyl‐γ‐valerolactones (PVL), the main circulating metabolites of flavan‐3‐ols and related dietary compounds in humans, to prevent AβO‐mediated toxicity.