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Nrf2-mediated cytoprotective effect of four different hyaluronic acids by molecular weight in human tenocytes.

J Drug Target. 2019; 
GalloriniMarialucia,BerardiAnna C,GissiClarissa,CataldiAmelia,OstiLeon
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Recombinant Proteins 5-30 μg/ml protein, Sigma-Aldrich, Milan, Italy) following the (ExpressPlus? 10x8, GenScript Biotech Corporation, China) and transferred to nitrocellulose membranes. Get A Quote

摘要

Non-traumatic rotator cuff tears (RCTs) are a frequent and potentially disabling injury. There is growing evidence that hyaluronic acid (HA) is effective for pain relief and to counteract inflammation in RCTs, however, its effective role in tendinopathies remains poorly studied. This study aims to disclose a possible molecular mechanism underlying the cytoprotective effects of four different HA preparations (Artrosulfur HA, Synolis VA, Hyalgan and Hyalubrix) under HO-induced oxidative stress. Expression-levels of Lactate dehydrogenase (LDH) released were quantified in cell supernatants, CD44 expression levels were analysed by fluorescence microscopy, the mitochondrial membrane depolarisation (TMRE a... More

關鍵詞

CD44,Nrf2,autophagy,hyaluronic acid,inflammation,molecular weight,oxidative stress,te
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