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Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix.

Br J Cancer. 2019;

Zhang Wenlong，Liu Ling，Su HuiFang，Liu Qin，Shen Jie，Dai Hanren，Zheng Wei，Lu Yan，Zhang Weijie，Bei Yuncheng，Shen Ping

Products/Services Used	Details	Operation
Codon Optimization	. The antihHER2 scFv encoding amino acid sequences was reverse translated, codon optimised, and synthesised as a single construct (Genscript, Jiangsu, China).	Get A Quote

摘要

The extracellular matrix (ECM) is essential for malignant tumour progression， as it is a physical barrier to various kinds of anticancer therapies. Matrix metalloproteinase (MMPs) can degrade almost all ECM components， and macrophages are an important source of MMPs. Studies using macrophages to treat tumours have shown that macrophages can enter tumour tissue to play a regulatory role.