国产精品久久久久久永久牛牛,55国产福利在线视频,成人午夜精品视频在线观看

至今,GenScript的服務及產品已被Cell, Nature, Science, PNAS等1300多家生物醫藥類雜志引用近萬次,處于行業領先水平。NIH、哈佛、耶魯、斯坦福、普林斯頓、杜克大學等約400家全球著名機構使用GenScript的基因合成、多肽服務、抗體服務和蛋白服務等成功地發表科研成果,再次證明GenScript 有能力幫助業內科學家Make research easy.

HBx regulates transcription factor PAX8 stabilization to promote the progression of hepatocellular carcinoma.

Oncogene. 2019; 
Wang Juan,Li Ning,Huang Ze-Bing,Fu Sha,Yu Song-Man,Fu Yong-Ming,Zhou Peng-Cheng,Chen Ruo-Chan,Zhou Rong-Rong,Huang Yan,Hu Xing-Wang,Fan Xue-
Products/Services Used Details Operation
Catalog Antibody The potential interaction of PAX8, HBx, and Skp2 was J. Wang et al. examined by immunoprecipitation using anti-Flag, anti-His (GenScript 66005-1-Ig), anti-HA (sc-57592), anti-Myc or isotype control, and visualized by immunoblot Get A Quote

摘要

Transcription factor PAX8 expression is upregulated in several types of cancers. However, little is known about the function of PAX8 in the progression of hepatoma and its regulatory mechanisms. Here, we show that PAX8 silencing inhibits the proliferation and clonogenicity of hepatoma cells and its growth in vivo. The HBV X protein (HBx) does not directly interacts, but stabilizes PAX8 by inhibiting proteasome-dependent ubiquitination and degradation. Furthermore, the E3 ubiquitin ligase complex component Skp2 through its LRR domain directly interacts with the Prd domain of PAX8 and targets PAX8 by recognizing its lysine 275 for ubiquitination and degradation in hepatoma cells. In addition, HBx direct... More

關鍵詞

              主站蜘蛛池模板: 连平县| 东山县| 墨玉县| 通榆县| 民勤县| 德庆县| 宝清县| 开封市| 绥中县| 大庆市| 黎川县| 江门市| 宁化县| 屏边| 当阳市| 布拖县| 土默特左旗| 深州市| 河间市| 乐安县| 沙雅县| 平湖市| 泽普县| 宁安市| 广平县| 中牟县| 富宁县| 申扎县| 麻栗坡县| 家居| 娱乐| 鸡西市| 锡林浩特市| 资中县| 吉木乃县| 潞城市| 闵行区| 大悟县| 镇雄县| 桂平市| 兴化市|