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Decreased expression of cystathionine β-synthase exacerbates intestinal barrier injury in ulcerative colitis.

J Crohns Colitis. 2019;

ChenShanwen，ZuoShuai，ZhuJing，YueTaohua，BuDingfang，WangXin，WangPengyuan，PanYisheng，LiuY

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Recombinant Proteins	… [21] . Nuclear protein extracts were prepared according to the manufacturer's instructions (Thermo Pierce, USA). Briefly, Caco-2 monolayers were washed with PBS and … electrophoresed in 4-12% polyacrylamide gels (GenScript). Subsequently, the Page 8. Accepted Manuscript …	Get A Quote

摘要

Endogenous hydrogen sulfide (H2S) regulates multiple physiological and pathological processes in colon epithelial tissues. The current study investigated the role of cystathionine β-synthase (CBS)， a major producer of H2S in colon epithelial cells， in the pathogenesis of UC-related intestinal barrier injury. The expression and DNA methylation level of CBS were investigated in inflamed and non-inflamed colon tissues collected from UC patients， and the effect of decreased CBS levels on Caco-2 monolayer barrier injury and altered status of tight junctions elicited by TNF/IFN was determined.