TGF-β 3, Human

Transforming growth factor beta 3(TGFB3) is a member of a TGF -β superfamily which is defined by their structural and functional similarities. TGFB3 is secreted as a complex with LAP. This latent form of TGFB3 becomes active upon cleavage by plasmin, matrix metalloproteases, thrombospondin -1, and a subset of integrins. It binds with high affinity to TGF- β RII, a type II serine/threonine kinase receptor. TGFB3 is involved in cell differentiation, embryogenesis and development. It is believed to regulate molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Without TGF-β3, mammals develop a deformity known as a cleft palate.

價(jià)格	￥1560
產(chǎn)品編號(hào)	Z03430
規(guī)格	10 μg 50 μg 1 mg 大單詢價(jià)
數(shù)量

產(chǎn)品簡(jiǎn)介圖例技術(shù)背景

產(chǎn)品簡(jiǎn)介

Species

Human

Protein Construction

TGF-β3 (Ala301-Ser412)
Accession # P10600

Purity

> 95% as analyzed by SDS-PAGE

Endotoxin Level

< 1 EU/μg of protein by LAL method

Biological Activity

ED₅₀ < 0.2 ng/ml, measured in a cell proliferation assay using mouse HT-2 cells.

Expression System

Human Cells

Apparent Molecular Weight

~12.7 kDa, on SDS-PAGE under reducing conditions.

Formulation

Lyophilized from a 0.2 μm filtered solution in 4 mM HCl.

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH?O up to 100 μg/ml.

Storage & Stability

Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.

圖例

Lane 1: 2 μg of TGF-β 3, Human, non-reducing (NR)
Lane 2: 2 μg of TGF-β 3, Human, reducing (R)
> 95% as analyzed by SDS-PAGE ?

技術(shù)背景

Target Background

Synonyms

Transforming growth factor beta-3; TGFB3; TGF-beta-3; Latency-associated peptide; LAP

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.

相關(guān)文獻(xiàn)

1. Ming Yi, et al. The construction, expression, and enhanced anti-tumor activity of YM101: a bispecific antibody simultaneously targeting TGF-β and PD-L1. J Hematol Oncol. (2021-02)

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TGF-β 3, Human

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