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Class A dioscorins of various yam species suppress ovalbumin-induced allergic reactions.

Immunopharmacol Immunotoxicol. 2014; 
Yang CC, Lin KC.
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Cellular Analysis … Endotoxin was removed by ToxinEraserTM endotoxin removal resin (GenScript, Piscataway, NJ) according to the manufacturer's protocol, which resulted in levels of 0.097–0.181 EU/mL as determined by ToxinSensorTM Chromogenic Limulus Amebocyte Lysate endotoxin … Get A Quote

摘要

Dioscorins, the primary storage proteins in yam tubers, of different species exhibited varying immunomodulatory activities in mice. We inferred that this might be attributed to the various isoforms in the yam tubers.,We aimed to investigate the antiallergic potential of the Class A dioscorins of various yam species using the ovalbumin (OVA)-induced murine allergy model.,We purified the recombinant Class A dioscorins (rDioscorins) of various yam species from Escherichia coli and evaluated their antiallergic potential by enzyme-linked immunosorbent assay.,The Class A rDioscorins of various yam species suppressed allergic reactions by significantly decreasing the serum IgE and histamine levels. The serum IFN-γ an... More

關鍵詞

Allergy; Th1/Th2 imbalance; herbal medicine; histamine; interferon-gamma
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